How pandemics strengthen links between viruses and autoimmunity
نویسندگان
چکیده
The body’s immune response to viruses has long been thought spark autoimmune disease. A virus affecting millions of people could help researchers finally know for sure.
منابع مشابه
Viruses and autoimmunity.
Viruses have been suspected as causes and contributors of human autoimmune diseases (AID), although direct evidence for the association is lacking. However, several animal models provide strong evidence that viruses can induce AIDs as well as act to accelerate and exacerbate lesions in situations where self-tolerance is broken. Many models support the hypothesis by acting as molecular mimics th...
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To explain the pathogenesis of autoimmunity, we hypothesize that following an infection the immune response spreads to tissue-specific autoantigens in genetically predisposed individuals eventually determining progression to disease. Molecular mimicry between viral and self antigens could, in some instances, initiate autoimmunity. Local elicitation of inflammatory cytokines following infection ...
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ژورنال
عنوان ژورنال: Nature
سال: 2021
ISSN: ['1476-4687', '0028-0836']
DOI: https://doi.org/10.1038/d41586-021-01835-w